Investigations at LTER Palmer site include:
- Physical forcing (solar, atmospheric, oceanic and sea ice) with emphasis on ecological consequences of annual and inter-annual variation
- Ecology and population biology of marine bacteria and archaeal, phytoplankton, zooplankton and seabirds
- Biogeochemical cycling of carbon and nitrogen
- Ecosystem responses to climate migration
- Physical/chemical/biological modeling linking ecosystem processes to environmental forcing

Old Palmer Station was established in 1965 with the current Palmer Station occupied starting in 1967. The National Science Foundation Office of Polar Programs in collaboration with the Division of Environmental Biology designated Palmer in 1990 as the first polar biome LTER site in the Southern Hemisphere. Logistics support for all Antarctic activity of the United States is provided by Raytheon Polar Services.